| Sickle cell biomechanics. | |
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MedLine Citation:
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PMID: 20455701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fragile, poorly deformable RBCs contribute to impaired blood flow and other pathophysiological aspects of the disease. The major underlying cause of this altered blood rheology and hemodynamics is hemoglobin S (HbS) polymerization and RBC sickling under deoxygenated conditions. This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease. |
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Authors:
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Gilda A Barabino; Manu O Platt; Dhananjay K Kaul |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of biomedical engineering Volume: 12 ISSN: 1545-4274 ISO Abbreviation: Annu Rev Biomed Eng Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-21 Revised Date: 2011-09-14 |
Medline Journal Info:
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Nlm Unique ID: 100883581 Medline TA: Annu Rev Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 345-67 Citation Subset: IM |
Affiliation:
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The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA. barabino@gatech.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Sickle Cell
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blood*,
physiopathology* Animals Biomechanics Cats Constriction, Pathologic Disease Models, Animal Erythrocyte Deformability* Erythrocyte Membrane / physiology Erythrocytes, Abnormal / pathology, physiology* Hemodynamics / physiology Hemoglobin, Sickle / metabolism Humans Rabbits Rats |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL070047-07/HL/NHLBI NIH HHS; R01 HL070047-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin, Sickle |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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