| Sick leave and disability pension before and after initiation of antirheumatic therapies in clinical practice. | |
| | |
MedLine Citation:
|
PMID: 21518724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: /st> To investigate sick leave and disability pension in rheumatoid arthritis (RA) in relation to the initiation of biological and non-biological antirheumatic therapies in clinical practice. METHODS: /st> Patients aged 19-60 years initiating non-biological mono (n=2796) or combination disease-modifying antirheumatic drug (DMARD) therapy (n=973), or biological agents (n=4787) were identified in the Swedish Rheumatology Quality Register between 1999 and 2007. Sick leave and disability pension data (1995-2010) were retrieved from national registers. RESULTS: /st> During the year before the start of mono DMARD, combination DMARD and biological treatment, 10%, 12% and 43% of patients received disability pension benefits, respectively. The corresponding combined annual sick leave and disability pension days were 78 (54+25), 132 (105+27) and 190 (79+111). Irrespective of treatment type, initiators were characterised by a history of increasing sick leave and disability pension. Treatment start was associated with a break in this trajectory: sick leave decreased while disability pension increased, resulting in a net stabilisation of total days. Higher levels of days on sick leave and disability pension at treatment start were observed in patients initiating biologics in 1999 (236 days/year) compared with 2007 (150 days/year; p<0.001), but the trajectory thereafter remained largely similar and contrasted markedly with the level in the general population. CONCLUSION: /st> Sick leave and disability pension increased rapidly before the initiation of antirheumatic therapy, which was associated with a halt but not a reversal of this development. Work ability is a metric of importance for clinical practice, signalling large remaining needs in the RA population, and the need for intervention earlier in the disease process. |
| | |
Authors:
|
M Neovius; J F Simard; L Klareskog; J Askling; |
Related Documents
:
|
15197694 - Surgical repair of the prolapsing anterior leaflet with chordal shortening. 6616794 - Closed mitral valvotomy: early results and long-term follow-up of 3724 consecutive pati... 8480644 - Factors determining late success after mitral balloon valvulotomy. 12578334 - Mitral valve re-replacement for impaired bioprosthesis after 19 years in a patient unde... 22360904 - Transapical versus conventional aortic valve replacement-a propensity-matched comparison. 22195354 - Does nickel allergy play a role in the development of in-stent restenosis? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-25 |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: - ISSN: 1468-2060 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk-taking behaviors of adolescents with extreme obesity: normative or not?
Next Document: B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.