Document Detail


Sic transit gloria: farewell to the epidermal transit amplifying cell?
MedLine Citation:
PMID:  18371376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.
Authors:
Philip H Jones; Benjamin D Simons; Fiona M Watt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell stem cell     Volume:  1     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2008-03-28     Completed Date:  2008-04-24     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Cell Lineage
Cell Proliferation
Epidermis / cytology*
Humans
Models, Biological
Stem Cells / cytology
Grant Support
ID/Acronym/Agency:
G0601740//Medical Research Council; MC_U105370181//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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