Document Detail


Sibling oocyte submission to IVF and ICSI in unexplained infertility patients: a potential assay for gamete quality.
MedLine Citation:
PMID:  16569328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to reduce total fertilization failure in unexplained infertility, sibling oocytes were submitted to both conventional IVF and intracytoplasmic sperm injection (ICSI). Two groups of ICSI embryos were compared in unexplained infertility patients: those derived from ICSI when IVF had failed to fertilize, and those derived from ICSI while their sibling oocytes were fertilized by IVF. The outcome of oocytes fertilized exclusively by ICSI (essential ICSI, n = 749) was compared with those fertilized both by IVF and ICSI (non-essential ICSI, n = 957) in all IVF patients treated for unexplained infertility at the Hadassah Hospital (1999-2002). The latter group was further subdivided into ICSI and IVF embryos. Total fertilization rate was 54%. Fertilization rates by ICSI were lower in the essential ICSI compared with the non-essential ICSI group, at 65 and 73% (P < 0.025). Pregnancy rates per embryo transfer in the essential ICSI group (49%), ICSI derived embryos group (55%) and IVF derived embryos (44%) from the non-essential ICSI group, were similar. Implantation rates were lower in the essential ICSI group as compared with the non-essential ICSI group (21 versus 32% respectively; P < 0.05) and 26% for IVF embryos. In conclusion, essential ICSI was associated with lower fertilization and implantation rates.
Authors:
David Shveiky; Alex Simon; Hagar Gino; Anat Safran; Aby Lewin; Benjamin Reubinoff; Neri Laufer; Ariel Revel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  12     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-29     Completed Date:  2006-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Affiliation:
In-Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Fertilization in Vitro*
Humans
Infertility / diagnosis,  therapy*
Male
Oocytes / physiology*
Siblings*
Sperm Injections, Intracytoplasmic*
Spermatozoa / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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