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Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.
MedLine Citation:
PMID:  23266727     Owner:  NLM     Status:  Publisher    
Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3β,19α-dihydroxyurso-12-ene-23,28-dioic acid 3-O-β-D-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-α-L- arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-β-D-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-α-L-arabinopyranoside (4), and 3-O-β-D- glucopyranosyl medicagenic acid 28-O-β-D-galactopyranosyl (1→4)-β-D- xylopyranosyl (1→4)-α-L-rhamnopyranosyl (1→2)-(4-O-acetyl)-[β-D-apiofuranosyl (1→3)]-β-D-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7 μM.
Yue-Lin Song; Ke-Wu Zeng; Tian-Xing Shi; Yong Jiang; Peng-Fei Tu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-21
Journal Detail:
Title:  Fitoterapia     Volume:  -     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
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