| Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. | |
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MedLine Citation:
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PMID: 23266727 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3β,19α-dihydroxyurso-12-ene-23,28-dioic acid 3-O-β-D-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-α-L- arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-β-D-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-α-L-arabinopyranoside (4), and 3-O-β-D- glucopyranosyl medicagenic acid 28-O-β-D-galactopyranosyl (1→4)-β-D- xylopyranosyl (1→4)-α-L-rhamnopyranosyl (1→2)-(4-O-acetyl)-[β-D-apiofuranosyl (1→3)]-β-D-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7 μM. |
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Authors:
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Yue-Lin Song; Ke-Wu Zeng; Tian-Xing Shi; Yong Jiang; Peng-Fei Tu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-21 |
Journal Detail:
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Title: Fitoterapia Volume: - ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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