Document Detail

Sialyltransferase levels and sialic acid concentrations in sera of patients with malignant melanomas.
MedLine Citation:
PMID:  475455     Owner:  NLM     Status:  MEDLINE    
Serum levels of sialyltransferase and sialic acid were measured in patients with malignant melanomas (n = 49), healthy control persons (n = 20), and patients with non-malignant skin disorders (n = 30). Both parameters were found to be higher in malignant melanoma patients than in healthy control persons, but they were not significantly higher in melanoma patients than in patients with benign skin disorders, unless widespread dissemination of metastases had occurred. The highest values were measured in patients with liver and lung metastases. No general correlation was found between sialyltransferase activities and sialic acid concentrations. Sialic acid concentrations seem to be a better index for tumor spreading than sialyltransferase activities. In early stages of the disease, shedding from tumor cells is not the major source of elevated serum levels of sialyltransferase and sialic acid, respectively.
W P Herrmann; W Gielen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of dermatological research     Volume:  265     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  321-9     Citation Subset:  IM    
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MeSH Terms
Melanoma / blood*,  enzymology
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Sialic Acids / blood*
Sialyltransferases / blood*
Skin Neoplasms / blood*
Transferases / blood*
Reg. No./Substance:
0/Sialic Acids; EC 2.-/Transferases; EC 2.4.99.-/Sialyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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