Document Detail

Sialyl oligosaccharides of human colostrum: changes in concentration during the first three days of lactation.
MedLine Citation:
PMID:  17587674     Owner:  NLM     Status:  MEDLINE    
Sialyl oligosaccharides of human milk/colostrum are generally believed to be of biological significance, for example with respect to anti-adhesion of pathogenic organism, providing precursors for biosynthesis of brain, and so on. However, the levels of each of the sialyl oligosaccharides in human colostrum have not so far been determined. The present study was designed to determine the concentrations of nine major sialyl oligosaccharides in human colostrum, collected during the first 3 d (days 1-3) from the start of lactation. We found that the concentration of 3'-sialyllactose was significantly higher on day 1 than on day 2 and 3, but the levels of 6'-sialyllactose and sialyllacto-N-tetraose a were higher on day 3 than on day 1. These results are consistent with the view that during the first 3 d of lactation, the concentration of sialyl oligosaccharides in human colostrum change in accordance with the physiological demands of newborn infants.
Sadaki Asakuma; Maiko Akahori; Kazumasa Kimura; Yoko Watanabe; Tadashi Nakamura; Makoto Tsunemi; Ikichi Arai; Yasuhiro Sanai; Tadasu Urashima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  71     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1447-51     Citation Subset:  IM    
Graduate School of Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Japan.
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MeSH Terms
Adaptation, Physiological
Colostrum / chemistry*,  metabolism
Lactation / metabolism*
Lactose / analogs & derivatives,  analysis
Milk, Human / chemistry
Oligosaccharides / analysis*,  biosynthesis
Time Factors
Reg. No./Substance:
0/3'-sialyllactose; 0/6'-sialyllactose; 0/NE 1530; 0/Oligosaccharides; 0/sialooligosaccharides; 63-42-3/Lactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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