| Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. | |
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MedLine Citation:
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PMID: 22057003 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sialic acid, a common terminal substitution of glycoconjugates, has been so far consistently identified in all vertebrates as well as in a growing number of bacterial species. It is assumed to be widely distributed among animal species of the deuterostome phylum, based on its identification in few echinoderm and all vertebrate species. However, whole sections of deuterostoma, especially those intermediate species between invertebrates and vertebrates including cephalochordates, urochordates and hemichordates, are still unexplored in term of sialylation capacities. The discovery of functional sialic acid machinery in some of these species may shed new light onto the evolution of glycosylation capacities in deuterostome lineage. In a first approach, we investigated the sialylation pattern of a cephalocordate species, Branchiostoma belcheri, which occupies a strategic phylogenetic position to understand the transition of invertebrates toward vertebrates. Structural analysis of B. belcheri glycoconjugates established that this organism synthesizes large quantities of various sialic acids, some of which presenting rare or novel structures such as methylated sialic acids. These sialic acids were shown to be in majority associated with mono- and di-sialylated core 1 type O-Glycans. Moreover, screening of the animal organs revealed the existence of exquisite tissues specificity in the distribution of sialic acids. Description of sialylation profiles was then correlated to the expression patterns of key enzymes involved in the biosynthesis of major forms of sialic acids, which provides the first complete overview of the sialylation patterns in cephalochordates. |
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Authors:
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Yann Guérardel; Lan-Yi Chang; Akiko Fujita; Bernadette Coddeville; Emmanuel Maes; Chihiro Sato; Anne Harduin-Lepers; Kaoru Kubokawa; Ken Kitajima |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-4 |
Journal Detail:
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Title: Glycobiology Volume: - ISSN: 1460-2423 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104124 Medline TA: Glycobiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Université de Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, UGSF, F-59650 Villeneuve d'Ascq, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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