Document Detail

Sialic acids and antimicrobial substances in the apocrine glands of porcine perianal skin.
MedLine Citation:
PMID:  22890608     Owner:  NLM     Status:  Publisher    
The porcine perianal skin shows prominent apocrine glands with large saccular dilatations, whereby the functional significance of the glandular secretions is rather unexplained. Our study focuses on the demonstration of sialoglycoconjugates and antimicrobial substances in these glands, using glycoconjugate histochemical and immunohistochemical methods. The result obtained emphasized the general presence of sialic acids, linked to α2-6Gal/GalNAc and α2-3Gaβl1-4GlcNAc, in the secretory cells. The secretory epithelium and luminal secretions also contained a spectrum of antimicrobial substances, such as lysozyme, IgA, lactoferrin, and the peptide group of β-defensins. Realizing that sialic acids possess diverging functional properties through various saccharide residues, and that antimicrobial substances serve as a non-specific defense against microorganisms, these secretory products may function as protective agents in order to preserve the integrity of the perianal region. This view includes that the amounts of bacteria on the skin surface are controlled and maintained at the certain level.
Takayuki Nara; Tadashi Yasui; Osamu Fujimori; Wilfried Meyer; Azuma Tsukise
Related Documents :
2201658 - Neuroendocrine aspects of cerebral aging.
8495338 - Serotonin depresses excitatory amino acid-induced excitation of cerebellar purkinje cel...
9399638 - Aspalatone, a new antiplatelet agent, attenuates the neurotoxicity induced by kainic ac...
7822118 - Excitotoxicity and neurological disorders: involvement of membrane phospholipids.
17617998 - Omega-3 fatty acids and athletics.
12189178 - Conversion of omnipotent translation termination factor erf1 into ciliate-like uga-only...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-14
Journal Detail:
Title:  Archives of dermatological research     Volume:  -     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The association between GJB2 gene polymorphism and psoriasis: a verification study.
Next Document:  Profiling of Substrates for Zinc-dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Ac...