Document Detail


Sialic acid value in pleural effusion as a diagnostic marker of malignancy.
MedLine Citation:
PMID:  24640868     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In differential diagnosis of pleural effusions, cytology is the most sensitive method. Since cytology findings are positive in half of such fluids, combined use of reliable tumor marker and cytology is a logical approach. Sialic acid and other tumor markers can be reliable substances associated with neoplasia. The present study measured sialic acid levels in pleural effusion and serum samples of patients with malignant and nonmalignant diseases to discriminate each other, and to diagnose malignant effusion in a simple, cheap and reliable way. Sixty patients with pleural effusion were enrolled in the study and classified into two groups, group (I) 30 patients with malignant pleural effusion, and group (II) 30 patients with nonmalignant pleural effusion. Pleural fluid (PF) and serum (S) levels of sialic acid were measured prior to any therapy; and PF/S sialic acid ratios were calculated. Pleural fluid and serum levels of sialic acid were significantly higher in malignant group compared to nonmalignant one. PF/S sialic acid ratio was higher in malignant group compared to nonmalignant group. In the malignant pleural effusion group, smokers showed a statistically significant higher pleural fluid and serum sialic acid levels as compared to nonsmokers. By using ROC curve, the cut off value of malignant pleural fluid sialic acid was 69.65 mg/dL, sensitivity was 70%, and specificity was 96%.
Authors:
Sherif Alsayed; Samar Marzouk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Egyptian Society of Parasitology     Volume:  43     ISSN:  1110-0583     ISO Abbreviation:  J Egypt Soc Parasitol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102141     Medline TA:  J Egypt Soc Parasitol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  689-96     Citation Subset:  IM    
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