Document Detail

Sialic acid, periodontal pathogens and Tannerella forsythia: stick around and enjoy the feast!
MedLine Citation:
PMID:  22230462     Owner:  NLM     Status:  MEDLINE    
Periodontal pathogens, like any other human commensal or pathogenic bacterium, must possess both the ability to acquire the necessary growth factors and the means to adhere to surfaces or reside and survive in their environmental niche. Recent evidence has suggested that sialic acid containing host molecules may provide both of these requirements in vivo for several periodontal pathogens but most notably for the red complex organism Tannerella forsythia. Several other periodontal pathogens also possess sialic acid scavenging enzymes - sialidases, which can also expose adhesive epitopes, but might also act as adhesins in their own right. In addition, recent experimental work coupled with the release of several genome sequences has revealed that periodontal bacteria have a range of sialic acid uptake and utilization systems while others may also use sialic acid as a cloaking device on their surface to mimic host and avoid immune recognition. This review will focus on these systems in a range of periodontal bacteria with a focus on Ta. forsythia.
G Stafford; S Roy; K Honma; A Sharma
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-12
Journal Detail:
Title:  Molecular oral microbiology     Volume:  27     ISSN:  2041-1014     ISO Abbreviation:  Mol Oral Microbiol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-04-12     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  101524770     Medline TA:  Mol Oral Microbiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  11-22     Citation Subset:  D    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Bacterial Adhesion
Bacteroides / enzymology*
Biofilms / growth & development*
Membrane Transport Proteins / metabolism
Molecular Mimicry
N-Acetylneuraminic Acid / metabolism*
Neuraminidase / metabolism*
Periodontitis / metabolism,  microbiology*
Virulence Factors
Grant Support
DE014749/DE/NIDCR NIH HHS; R185/0211//The Dunhill Medical Trust
Reg. No./Substance:
0/Membrane Transport Proteins; 0/Virulence Factors; EC; GZP2782OP0/N-Acetylneuraminic Acid

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