| Sialic acid, periodontal pathogens and Tannerella forsythia: stick around and enjoy the feast! | |
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MedLine Citation:
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PMID: 22230462 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Periodontal pathogens, like any other human commensal or pathogenic bacterium, must possess both the ability to acquire the necessary growth factors and the means to adhere to surfaces or reside and survive in their environmental niche. Recent evidence has suggested that sialic acid containing host molecules may provide both of these requirements in vivo for several periodontal pathogens but most notably for the red complex organism Tannerella forsythia. Several other periodontal pathogens also possess sialic acid scavenging enzymes - sialidases, which can also expose adhesive epitopes, but might also act as adhesins in their own right. In addition, recent experimental work coupled with the release of several genome sequences has revealed that periodontal bacteria have a range of sialic acid uptake and utilization systems while others may also use sialic acid as a cloaking device on their surface to mimic host and avoid immune recognition. This review will focus on these systems in a range of periodontal bacteria with a focus on Ta. forsythia. |
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Authors:
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G Stafford; S Roy; K Honma; A Sharma |
Publication Detail:
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Type: Journal Article Date: 2011-11-12 |
Journal Detail:
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Title: Molecular oral microbiology Volume: 27 ISSN: 2041-1014 ISO Abbreviation: Mol Oral Microbiol Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101524770 Medline TA: Mol Oral Microbiol Country: Denmark |
Other Details:
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Languages: eng Pagination: 11-22 Citation Subset: D |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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