Document Detail

Sialic acid metabolism in regenerating rat liver.
MedLine Citation:
PMID:  7306957     Owner:  NLM     Status:  MEDLINE    
Sialic acid metabolism was investigated in control rat liver, in regenerating liver at 24 h and 48 h after partial hepatectomy and in the liver of sham-operated animals. High levels of membrane-bound neuraminidase, with no detectable changes in the soluble enzyme, were observed in regenerating rat liver. The neuraminidase activities in the liver of sham-operated rats were identical to those present in control liver. High levels of CMP-N-acetylneuraminic acid synthetase and sialyltransferase were observed both in regenerating liver as well as in the liver of sham-operated rats. The sialic acid content of regenerating rat liver, which was lower than that found in the liver of control and sham-operated rats at 24 h, returned to normal values 48 h after surgery.
G S Kishore; R Carubelli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  13     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  281-9     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / enzymology
Liver / metabolism*,  ultrastructure
Liver Regeneration*
N-Acylneuraminate Cytidylyltransferase / metabolism
Neuraminidase / metabolism
Sialic Acids / metabolism*
Sialyltransferases / metabolism
Time Factors
Grant Support
Reg. No./Substance:
0/Sialic Acids; EC 2.4.99.-/Sialyltransferases; EC Cytidylyltransferase; EC

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