| Sialic acid expression in autoimmune thyroiditis. | |
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MedLine Citation:
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PMID: 12553699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmune diseases of the thyroid gland are among the most frequent endocrine disorders. The present study analyzes expression patterns of sialic acids in these diseases. Three lectins specific for sialic acids were used for the histochemical analysis of surgical specimens of the thyroid gland: Tritrichomonas mobilensis lectin that stains all types of sialic acids, Maackia amurensis leukoagglutinin that stains sialic acids with alpha2,3 linkage and Sambucus nigra agglutinin that stains sialic acids with alpha2,6 linkage. In autoimmune thyroiditis, there was a significant increase in sialic acid expression in epithelial cells, especially on luminal membranes of follicular cells. The alpha2,3 linkage dominated over the alpha2,6 linkage. Lymphocytes of patients with Hashimoto thyroiditis, especially in germinal centers, showed strong expression of alpha2,6-linked sialic acids on their cell membrane. Vascular endothelium was positive in all specimens. It can be concluded, that there is a significant increase in sialic acid expression in autoimmune diseases of the thyroid gland, predominantly of sialic acids with alpha2,3 linkage, whereas the sialylation pattern of lymphocytes in Hashimoto thyroiditis was also different. |
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Authors:
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Pavol Janega; Andrea Cerná; Ivana Kholová; Eva Brabencová; Pavel Babál |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta histochemica Volume: 104 ISSN: 0065-1281 ISO Abbreviation: Acta Histochem. Publication Date: 2002 |
Date Detail:
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Created Date: 2003-01-29 Completed Date: 2003-06-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370320 Medline TA: Acta Histochem Country: Germany |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Medical Faculty, Comenius University, Bratislava, Slovakia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glycoproteins Goiter / metabolism, pathology Graves Disease / metabolism, pathology Humans Immunoenzyme Techniques N-Acetylneuraminic Acid / metabolism* Phytohemagglutinins Plant Lectins Ribosome Inactivating Proteins Thyroiditis, Autoimmune / metabolism*, pathology Tritrichomonas / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Phytohemagglutinins; 0/Plant Lectins; 0/Sambucus nigra lectins; 0/leukoagglutinins, plants; 131-48-6/N-Acetylneuraminic Acid; EC 3.2.2.22/Ribosome Inactivating Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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