| Sialic acid-containing milk proteins show differential immunomodulatory activities independent of sialic acid. | |
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MedLine Citation:
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PMID: 16190615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunomodulatory activities of four sialic acid-containing milk proteins (kappa-casein, glycomacropeptide, lactoferrin, and proteose peptone-3 component) were determined, and the role of sialic acid was evaluated. Two in vitro models were used: murine splenocyte proliferation, where the effect on LPS-, Con A-, and PHA-stimulated proliferation was studied, and cytokine production in LPS-stimulated murine dendritic cells (DC). All four proteins inhibited LPS-induced splenocyte proliferation, though to different degrees, and independently of sialic acid. kappa-Casein strongly inhibited PHA-induced proliferation and had a weak inhibitory effect on Con A-induced proliferation, whereas lactoferrin stimulated Con A-induced proliferation. kappa-Casein, glycomacropeptide, and lactoferrin differentially affected cytokine production by DC: kappa-casein significantly inhibited production of TNF-alpha, IL-10, -12, -6, and -1beta, independent of sialic acid, whereas less-marked effects of glycomacropeptide and lactoferrin were seen. These findings thus point to important immunosuppressive effects of some milk proteins and indicate that they may function via different mechanisms. |
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Authors:
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Trine L Mikkelsen; Susanne Bakman; Esben S Sørensen; Vibeke Barkholt; Hanne Frøkiaer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 53 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-29 Completed Date: 2005-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 7673-80 Citation Subset: IM |
Affiliation:
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BioCentrum-DTU, Biochemistry and Nutrition, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caseins / pharmacology Cell Division / drug effects Concanavalin A / pharmacology Cytokines / biosynthesis Dendritic Cells / drug effects, immunology Immunity / drug effects* Lactoferrin / pharmacology Lipopolysaccharides / pharmacology Mice Milk Proteins / chemistry*, pharmacology* N-Acetylneuraminic Acid / analysis* Neuraminidase / pharmacology Phytohemagglutinins / pharmacology Spleen / cytology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Cytokines; 0/Lactoferrin; 0/Lipopolysaccharides; 0/Milk Proteins; 0/Phytohemagglutinins; 11028-71-0/Concanavalin A; 131-48-6/N-Acetylneuraminic Acid; EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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