Document Detail

Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
MedLine Citation:
PMID:  17882259     Owner:  NLM     Status:  MEDLINE    
Cytochrome c oxidase (complex IV) of the respiratory chain is assembled from nuclear and mitochondrially-encoded subunits. Defects in the assembly process lead to severe human disorders such as Leigh syndrome. Shy1 is an assembly factor for complex IV in Saccharomyces cerevisiae and mutations of its human homolog, SURF1, are the most frequent cause for Leigh syndrome. We report that Shy1 promotes complex IV biogenesis through association with different protein modules; Shy1 interacts with Mss51 and Cox14, translational regulators of Cox1. Additionally, Shy1 associates with the subcomplexes of complex IV that are potential assembly intermediates. Formation of these subcomplexes depends on Coa1 (YIL157c), a novel assembly factor that cooperates with Shy1. Moreover, partially assembled forms of complex IV bound to Shy1 and Cox14 can associate with the bc1 complex to form transitional supercomplexes. We suggest that Shy1 links Cox1 translational regulation to complex IV assembly and supercomplex formation.
David U Mick; Karina Wagner; Martin van der Laan; Ann E Frazier; Inge Perschil; Magdalena Pawlas; Helmut E Meyer; Bettina Warscheid; Peter Rehling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-20
Journal Detail:
Title:  The EMBO journal     Volume:  26     ISSN:  1460-2075     ISO Abbreviation:  EMBO J.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-17     Completed Date:  2007-12-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  4347-58     Citation Subset:  IM    
Institut für Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universität Freiburg, Freiburg, Germany.
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MeSH Terms
DNA, Mitochondrial / metabolism
Electron Transport
Electron Transport Complex IV / metabolism*
Gene Expression Regulation, Fungal*
Genes, Fungal
Membrane Proteins / metabolism,  physiology*
Mitochondria / metabolism
Mitochondrial Proteins / metabolism
Models, Biological
Protein Binding
Protein Biosynthesis*
Protein Interaction Mapping
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / physiology*
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Membrane Proteins; 0/Mitochondrial Proteins; 0/SHY1 protein, S cerevisiae; 0/Saccharomyces cerevisiae Proteins; 0/Surf-1 protein; EC Transport Complex IV

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