Document Detail

Shunting, release, and distribution of nine and fifteen micron spheres in myocardium.
MedLine Citation:
PMID:  1273749     Owner:  NLM     Status:  MEDLINE    
The shunting, release, and transmural distribution of 9 and 15 mu radioactive microspheres were compared in isolated hearts and intact hearts with and without adenosine triphosphate (ATP) vasodilation. ATP vasodilation caused increase shunting of 9 mu spheres but not 15 mu spheres (p less than 0.05). The transmural distribution of 9 and 15 mu spheres in left ventricle and septum were significantly different (p less than 0.01) and the difference was characteristic for the isolated heart and the nonvasodilated intact heart. There was no difference in distribution across the right ventricle. There appear to be significant differences in regional shunting as well as distribution in the intact heart. We found no systematic correction for comparing flows measured with 9 and 15 mu spheres.
W G Marshall; G B Boatman; G Dickerson; A Perlin; E P Todd; J R Utley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  79     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphate / pharmacology
Coronary Circulation* / drug effects
Coronary Vessels / drug effects
Heart Ventricles
Particle Size
Vasodilator Agents
Reg. No./Substance:
0/Vasodilator Agents; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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