Document Detail

Shunt quantification by mathematical analysis of indicator dilution curves.
MedLine Citation:
PMID:  352532     Owner:  NLM     Status:  MEDLINE    
Mathematical models are presented for describing and analyzing indicator dilution curves recorded in patients with intracardiac and great vessel shunts. The models treat individual segments of the circulation as linear system blocks, each having, at its output, a characteristic time response to a rapid injection of indicator at its input. These blocks are combined in feedback and feed-forward configurations to simulate left-to-right, right-to-left, and bidirectional shunts. A shunt analysis algorithm, using discrete analogs of the linear system models, was implemented in a computer program and used to analyze thermodilution curves recorded in patients with congenital heart defects. Results are presented comparing shunt fractions obtained from thermodilution curve analyses with oximetrically determined values in 20 patients. Comparing left-to-right shunts measured by the two methods, the mean systematic difference was 0.7% of pulmonary flow and the standard deviation was 7.6% of pulmonary flow. Statistical validation of the bidirectional shunt method will require acquisition and analysis of more data; however, reasonable shunt fractions were computed in five cases studied and good agreement with oximetric determinations was obtained in two cases where complete oximetric data were available.
R G Billings; J S Clark; L G Veasy; C A Cutler
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  4     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1978  
Date Detail:
Created Date:  1978-09-29     Completed Date:  1978-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-62     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Heart Defects, Congenital / physiopathology*
Heart Septal Defects, Atrial / physiopathology
Heart Septal Defects, Ventricular / physiopathology
Indicator Dilution Techniques*
Models, Biological*
Pulmonary Circulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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