Document Detail

Should we treat patients with moderately severe stenosis of the left main coronary artery and negative FFR results?
MedLine Citation:
PMID:  15282411     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The prognostic importance of significant left main coronary artery disease is unequivocal. However, moderate lesions of the left main coronary artery (LMCA) are sometimes found in patients presenting significant stenosis in other coronary arteries or equivocal symptoms. The ability of myocardial fractional flow reserve (FFR) to predict coronary events could be useful in the decision-making process in these patients. The present study was designed to investigate the occurrence of cardiac events in patients with coronary syndromes and LMCA stenosis of moderate severity in whom FFR failed to show an haemodynamic significant repercussion of the LMCA. METHODS AND RESULTS: We studied 27 consecutive patients (mean age 62.7 +/- 10.5 years) with moderate stenoses (30-50%) of the LMCA. In seven patients who presented significantly reduced FFR (< 0.75) at the LMCA level (Group A), coronary revascularization of this vessel was performed. In 20 patients with negative FFR (greater than or equal to 0.75) at the LMCA level (Group B), the LMCA stenosis was not revascularized, being the revascularization procedures (if any) limited to other arteries with significant obstructions. During a mean follow-up period of 26.2 +/- 12.1 months, clinical events occurred in 3 patients in the whole group. One patient with positive FFR died during coronary bypass surgery. Two group B patients were surgically revascularized 4 months and 4 years after the initial coronariography. CONCLUSIONS: Patients with coronary lesions of moderate severity on the LMCA and negative FFR may constitute a subgroup of good prognosis in the follow-up. Our findings suggest that negative FFR is a potentially useful indicator of the likelihood of cardiac events, and thus represents a useful aid in clinical decision-making in the hemodynamics laboratory.
Manuel Jiménez-Navarro; José Maria Hernández-García; Juan H Alonso-Briales; Birgit Kühlmorgen; Juan José Gómez-Doblas; José Manuel García-Pinilla; Raúl López-Salguero; Eduardo de Teresa Galván
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  16     ISSN:  1042-3931     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-29     Completed Date:  2004-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-400     Citation Subset:  IM    
Servicio de Cardiologia, Unidad de Hemodinamica, Hospital Clinico Universitario Virgen de la Victoria, Campus de Teatinos s/n, E-29010 Malaga, Spain.
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MeSH Terms
Coronary Angiography
Coronary Circulation / physiology*
Coronary Stenosis / physiopathology,  radiography*,  therapy*
Decision Making
Middle Aged
Myocardial Revascularization* / utilization
Prospective Studies
Severity of Illness Index
Treatment Outcome
Comment In:
J Invasive Cardiol. 2004 Aug;16(8):401   [PMID:  15282412 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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