| Should we monitor vitamin B12 levels in patients who have had end-ileostomy for inflammatory bowel disease? | |
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MedLine Citation:
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PMID: 14618349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: We examined whether vitamin B12 levels are low following surgery in those patients who have had end-ileostomy for inflammatory bowel disease. PATIENTS AND METHODS: This prospective observational study used the database of a university teaching hospital to identify patients with inflammatory bowel disease with an end-ileostomy constructed more than 30 months previously. Precise diagnosis, disease distribution and details of their surgery were collected from case notes of the 39 eligible patients (18 Crohn's disease, 17 ulcerative colitis, 4 indeterminate colitis). Mean duration since ileostomy formation was 12.53 years. Patients found to be vitamin B12 deficient underwent further investigations to ascertain the cause of their vitamin B12 deficiency (<150 ng/l). RESULTS: There was no significant difference between serum vitamin B12 levels in patients with Crohn's disease and those in patients with ulcerative colitis following end ileostomy formation. Two patients (5.1%) were identified as having vitamin B12 deficiency. One of these had had a panproctocolectomy for Crohn's disease, followed by subsequent resection for ileal obstruction and ongoing small intestinal disease. The other had had colectomy for ulcerative colitis, in whom no cause other than the ileostomy was found for the vitamin B12 deficiency. There was no significant correlation between serum vitamin B12 levels and duration of ileostomy overall or in the disease subgroups. CONCLUSION: We do not recommend routine screening for vitamin B12 deficiency in this group of patients unless they have undergone additional small bowel resection or have ongoing small bowel inflammation. |
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Authors:
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A Jayaprakash; T Creed; L Stewart; B Colton; R Mountford; G Standen; C Probert |
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Publication Detail:
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Type: Journal Article Date: 2003-11-15 |
Journal Detail:
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Title: International journal of colorectal disease Volume: 19 ISSN: 0179-1958 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-03 Completed Date: 2004-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 316-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, UK. jaypy@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Ileostomy / adverse effects* Inflammatory Bowel Diseases / blood*, surgery* Male Middle Aged Prevalence Prospective Studies Vitamin B 12 / blood* Vitamin B 12 Deficiency / diagnosis, etiology |
| Chemical | |
Reg. No./Substance:
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68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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