Document Detail

Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?
MedLine Citation:
PMID:  22189742     Owner:  NLM     Status:  MEDLINE    
Although the prophylactic administration of indomethacin in extremely low-birth weight infants reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage, it does not appear to provide any long-term benefit in terms of survival without neurosensory and cognitive outcomes. Considering the increased drug-induced reduction in renal, intestinal, and cerebral blood flow, the use of prophylaxis cannot be routinely recommended in preterm neonates. However, a better understanding of the genetic background of each infant may allow for individualized prophylaxis using NSAIDs and metabolomics.
Vassilios Fanos; Michele Pusceddu; Angelica Dessì; Maria Antonietta Marcialis
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-04-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  2141-9     Citation Subset:  IM    
Neonatal Intensive Care Unit, Puericulture Institute And Neonatal Section, AOU University of Cagliari, Italy.
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MeSH Terms
Cyclooxygenase Inhibitors / therapeutic use*
Ductus Arteriosus, Patent / prevention & control*
Ibuprofen / therapeutic use*
Indomethacin / therapeutic use*
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / prevention & control*
Intracranial Hemorrhages / prevention & control
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 15687-27-1/Ibuprofen; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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