| Should we consider MMF therapy after rituximab for nephrotic syndrome? | |
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MedLine Citation:
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PMID: 21533869 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The management of steroid-dependent nephrotic syndrome, especially in patients who have failed to respond to cytotoxic drugs, such as cyclophosphamide, remains challenging. Rituximab represents a new (off-label) therapeutic option. In a significant portion of patients, it has a short serum half-life following the recovery of CD20-positive cells. The addition of mycophenolate mofetil (MMF) as a maintenance therapy is also an attractive option, but one which requires testing in a prospective randomized clinical trial with therapeutic drug monitoring and mechanistic ancillary studies. |
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Authors:
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Guido Filler; Shih-Han Susan Huang; Ajay P Sharma |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-1 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: - ISSN: 1432-198X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, Schulich School of Medicine & Dentistry, London, ON, Canada, N6A 5W9, guido.filler@lhsc.on.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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