| Should we change our lipid management strategies to focus on non-high-density lipoprotein cholesterol? | |
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MedLine Citation:
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PMID: 20852414 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Despite aggressive low-density lipoprotein cholesterol lowering, patients continue to be at significant risk of cardiovascular events. Assessment of non-high-density lipoprotein cholesterol (non-HDL-C) provides a measure of cholesterol contained in all atherogenic particles. In the third Adult Treatment Panel guidelines, non-HDL-C was introduced as a secondary target of therapy. RECENT FINDINGS: A combined post-hoc analysis of data from two prospective, randomized trials assessing the role of statins in patients with established coronary heart disease showed that on-treatment levels of non-HDL-C were more closely associated with cardiovascular outcomes than levels of low-density lipoprotein cholesterol. A recent meta-analysis of the relationship between non-HDL-C reduction and coronary heart disease risk showed that most lipid-modifying drugs used as monotherapy have a 1 : 1 relationship between percentage non-HDL-C lowering and percentage coronary heart disease reduction. In the European Prospective Investigation Into Cancer and Nutrition-Norfolk prospective population study (n = 21,448), participants with high non-HDL-C levels were at increased coronary heart disease risk independently of their low-density lipoprotein cholesterol levels. SUMMARY: Because non-HDL-C appears to be superior for risk prediction beyond low-density lipoprotein cholesterol, future guidelines should emphasize the importance of non-HDL-C for guiding cardiovascular prevention strategies. There is an increased need to have non-HDL-C reported on routine lipid panels, especially because it would be at no added cost. |
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Authors:
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Jamal S Rana; S Matthijs Boekholdt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in cardiology Volume: 25 ISSN: 1531-7080 ISO Abbreviation: Curr. Opin. Cardiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608087 Medline TA: Curr Opin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 622-6 Citation Subset: IM |
Affiliation:
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Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, California, USA. jamal.rana@cshs.org |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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