Document Detail

Should the use of probiotics in the preterm be routine?
MedLine Citation:
PMID:  20870904     Owner:  NLM     Status:  In-Data-Review    
Does the clinical trials' evidence of benefit justify the routine use of probiotics in the preterm infant? There are many uncertainties surrounding the use of probiotics in the preterm, including the mechanism(s) of action of probiotics, knowledge of who benefits and who might not, whether it is placement of large numbers of bacteria into the small intestine or colonisation that determines efficacy, the forms of microbial adaptation(s) and ecological consequences. There is also a current lack of defined products with associated evidence of safety in the preterm infant. It is argued that one cannot assume safety because of a lack of evidence of harm and that one should take a precautionary approach to the introduction of probiotics into routine neonatal practice. One should also consider how best one might monitor microbiological and ecological consequences and longer-term health outcomes before the introduction of this novel intervention into routine practice.
Michael Millar; Mark Wilks; Paul Fleming; Kate Costeloe
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Publication Detail:
Type:  Journal Article     Date:  2010-09-24
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  97     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F70-4     Citation Subset:  AIM; IM    
Department of Infection, Barts and The London NHS Trust, Pathology and Pharmacy Building, 3rd Floor, 80 Newark St, Whitechapel, London E1 2ES, UK;
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