Document Detail

Should the use of DDT be revived for malaria vector control?
MedLine Citation:
PMID:  12596442     Owner:  NLM     Status:  MEDLINE    
Indoor residual spraying with DDT was the principle method by which malaria transmission was eradicated or greatly reduced in many countries between the late 1940s and 1970s. Since then, decreasing use of DDT has been associated with a resurgence of malaria in India, Sri Lanka, former Soviet Central Asia, Zanzibar, Venezuela and several other Latin American countries. In India and Zanzibar, DDT resistance in vectors, as well as a decline in spray coverage, are probable causes of reduced effectiveness of DDT in recent decades. In southern Europe, eradication of malaria transmission was achieved by DDT spraying in the 1940s and 50s and eradication has been sustained by adequate treatment of imported human malaria cases. In the highlands of Madagascar and South Africa, recent reversion to DDT spraying has been successful in stemming resurgences of malaria. Continued use of DDT for vector control, but not for agriculture, is approved by the Stockholm Convention on Persistent Organic Pollutants. DDE residues in breast milk have been associated with DDT anti-malaria spraying in South Africa, but it is not known whether this is harmful. A claimed association of DDE residues with breast cancer have not been substantiated. There is a recent report of association of DDE residues with probability of premature birth; the possible relevance of this to anti-malarial use of DDT should be investigated. In Colombia, testing of the DDT stockpile for suspensibility, DDT resistance in Anopheles darlingi and investigation of the present affordability of widespread spraying with DDT, compared with alternative chemicals, are recommended.
Chris F Curtis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomédica : revista del Instituto Nacional de Salud     Volume:  22     ISSN:  0120-4157     ISO Abbreviation:  Biomedica     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205605     Medline TA:  Biomedica     Country:  Colombia    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM    
London School of Hygiene and Tropical Medicine, London, United Kingdon.
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MeSH Terms
Anopheles / parasitology
DDT / adverse effects,  therapeutic use*
Insect Vectors / parasitology
Insecticide Resistance
Insecticides / adverse effects,  therapeutic use*
Malaria / epidemiology,  prevention & control*,  transmission
Mosquito Control / methods*
Reg. No./Substance:
0/Insecticides; 50-29-3/DDT

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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