Document Detail


Should torsemide be the loop diuretic of choice in systolic heart failure?
MedLine Citation:
PMID:  23013124     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure (HF), yet torsemide has been shown to have less inter- and intra-individual variation in bioavailability and a longer duration of action compared with furosemide. Thus, a systematic review and meta-analysis of randomized controlled trials comparing torsemide versus furosemide in patients with systolic HF using OVID MEDLINE, Excerpta Medica (Embase), Web of Science, PubMed and Google Scholar was performed. Extracted data included study design, sample characteristics, intervention, outcomes and control for potential confounding factors. A DerSimonian and Laird random-effects model was used to compute summary risk ratios for HF and cardiovascular (CV) readmission outcomes. Two randomized trials comparing furosemide with torsemide in 471 patients with systolic HF were identified. Compared to furosemide, torsemide significantly reduced total HF readmissions (relative risk [RR]: 0.41, 95% CI: 0.28-0.61, p < 0.0001) and HF readmissions (RR: 0.53, 95% CI: 0.33-0.84, p = 0.008) as well as CV readmissions (RR: 0.77, 95% CI: 0.60-0.98, p = 0.03) in patients with "at least 1 readmission." Moreover, compared with furosemide, torsemide caused a 14% reduction in all-cause mortality (RR: 0.86 [0.53-1.39], p = 0.54). Compared with furosemide, torsemide significantly reduces HF and CV-related hospital readmissions in systolic HF. Furthermore, torsemide is associated with a trend in reducing all-cause mortality.
Authors:
James J Dinicolantonio
Related Documents :
8389514 - Pre-pregnancy risk factors of small-for-gestational age births among parous women in sc...
23225264 - Behavioral obligation and information avoidance.
10957864 - Births: preliminary data for 1999.
24406964 - Injury risk for rear-seated occupants in small overlap crashes.
22891394 - Postpartum post-traumatic stress disorder symptoms: the uninvited birth companion.
22492384 - Intimate partner violence and prescription of potentially addictive drugs: prospective ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future cardiology     Volume:  8     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  707-28     Citation Subset:  IM    
Affiliation:
Wegmans Pharmacy, Ithaca, 500 South Meadow Street, Ithaca, NY 14850, USA. jjdinicol@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The second law of thermodynamics and the heart.
Next Document:  Exercise-based cardiac rehabilitation in patients with coronary heart disease: meta-analysis outcome...