| Should thrombolysis have a greater role in the management of pulmonary embolism? | |
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MedLine Citation:
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PMID: 19886101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary embolism (PE) continues to be associated with significant mortality despite advances in the diagnostic techniques available for its detection. Anticoagulation remains standard treatment in PE although there is a consensus view that 'step-up' to thrombolytic therapy in addition to anticoagulation is indicated in those patients who are systemically shocked at presentation--a group defined as having suffered 'massive pulmonary embolism'. Considerable research has been directed at attempting to identify further groups of patients with PE who are at high risk of morbidity and mortality--notably those who are labelled as having suffered 'sub-massive pulmonary embolism' where this is defined as the presence of right-heart strain in the absence of systemic shock. In particular, the potential benefit of extending thrombolytic therapy to include those patients with sub-massive PE has been the subject of much enquiry and debate. This review examines the evidence for thrombolytic therapy and explores the potential for risk stratification in PE. |
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Authors:
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Peter O Jenkins; Javed Sultanzadeh; Manasi Bhagwat; Paul F Jenkins |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical medicine (London, England) Volume: 9 ISSN: 1470-2118 ISO Abbreviation: Clin Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-04 Completed Date: 2009-12-01 Revised Date: 2010-05-04 |
Medline Journal Info:
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Nlm Unique ID: 101092853 Medline TA: Clin Med Country: England |
Other Details:
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Languages: eng Pagination: 431-5 Citation Subset: IM |
Affiliation:
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Worthing Hospital. pjenkins@meddent.uwa.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Fibrinolytic Agents / therapeutic use* Humans Pulmonary Embolism / diagnosis*, drug therapy*, physiopathology Risk Assessment Thrombolytic Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fibrinolytic Agents |
| Comments/Corrections | |
Comment In:
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Clin Med. 2010 Apr;10(2):204-5; author reply 205
[PMID:
20438004
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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