Document Detail

Should physicians prescribe metformin to women with polycystic ovary syndrome PCOS?
MedLine Citation:
PMID:  20079483     Owner:  NLM     Status:  MEDLINE    
1. Metformin is not efficient enough in order to regulate menstrual cycles. 2.Metformin is not efficient enough in order to treat hyperandrogenism. 3. Metformin should not be used as a first-line treatment in order to treat infertility. Clomiphene citrate (CC) is the reference treatment. 4. Metformin in addition to CC is not recommended as a second line treatment, after the failure of CC alone. 5. Metformin should not be used during pregnancy in non diabetic women with PCOS, in order to prevent the risk of gestational diabetes. 6. Metformin should be prescribed to PCOS women when they are diabetic, in order to prevent their cardiovascular risk, after lifestyle modification. 7. Metformin should not be used in PCOS non diabetic women in order to lose weight. Metformin should not be used in order to treat dyslipidemia in women with PCOS. 8. In PCOS women, without diabetes, but with fasting hyperglycemia or carbohydrate intolerance, metformin should be prescribed if: BMI>35.
L Duranteau; P Lefevre; N Jeandidier; T Simon; S Christin-Maitre
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-15
Journal Detail:
Title:  Annales d'endocrinologie     Volume:  71     ISSN:  0003-4266     ISO Abbreviation:  Ann. Endocrinol. (Paris)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116744     Medline TA:  Ann Endocrinol (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009. Published by Elsevier Masson SAS.
Service d'endocrinologie p?diatrique, h?pital Saint-Vincent-de-Paul, 82 avenue Denfert-Rochereau, Paris, France.
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MeSH Terms
Body Mass Index
Clomiphene / therapeutic use
Diabetes Mellitus / drug therapy
Diabetes, Gestational / drug therapy
Fertility Agents, Female / therapeutic use
Hyperandrogenism / complications
Hypoglycemic Agents / adverse effects,  therapeutic use*
Infertility, Female / drug therapy
Menstrual Cycle / drug effects
Metformin / adverse effects,  therapeutic use*
Polycystic Ovary Syndrome / drug therapy*,  etiology
Reg. No./Substance:
0/Fertility Agents, Female; 0/Hypoglycemic Agents; 657-24-9/Metformin; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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