Document Detail


Should magnesium therapy be considered for the treatment of coronary heart disease? I. A critical appraisal of current facts and hypotheses.
MedLine Citation:
PMID:  7999528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When given at physiological doses, therapy with magnesium corrects the alterations in cellular function resulting from magnesium deficiency, whereas at higher dosages, which induce hypermagnesaemic levels, magnesium possesses pharmacological effects, such as the inhibition of the calcium influx: this may alter the electrophysiological properties of heart cells, decrease catecholamine secretion, influence the synthesis of prostacyclin and/or alter platelet function. The evidence that magnesium deficiency has untoward effects in patients with ischaemic heart disease is only circumstantial and direct proof that magnesium deficiency causes cardiac disorders is at present lacking. A ubiquitous calcium-channel blockade mechanism is the main and well-established way of action whereby magnesium acts at pharmacological levels; other mechanisms may be involved as well but at present remain questionable or unsettled. On the basis of the present knowledge, beneficial effects may thus be expected from high dose intravenous magnesium therapy in the setting of acute myocardial infarction with respect to mortality rates, even when there is concurrent thrombolytic therapy, as recently demonstrated by the large LIMIT-2 study, although this could not be confirmed from the ISIS-4 trial. High dose intravenous magnesium is also a first choice therapy for terminating torsade de pointes ventricular tachycardia but cannot be considered an established therapy for other cardiac rhythm disturbances nor for settings other than acute myocardial infarction in the case of ischaemic heart disease. The preliminary evidence that magnesium deficiency has a high prevalence in patients with ischaemic heart disease and that it may have a detrimental influence on the course of ischaemic heart disease needs to be validated by larger prospective and controlled clinical studies. Magnesium therapy in ischaemic heart disease thus proves a promising approach which, however, requires that the respective pharmacological and physiological effects be distinguished and further delineated and that the type and stage of ischaemic heart disease be characterized.
Authors:
M Weiss; B Lasserre
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  7     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1995-01-25     Completed Date:  1995-01-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Anna Seiler Haus, Inselspital, Berne, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / drug therapy*
Heart / drug effects,  physiology
Heart Diseases / complications
Humans
Magnesium / pharmacology,  therapeutic use*
Magnesium Deficiency / complications,  epidemiology,  physiopathology*
Myocardial Infarction / drug therapy
Myocardial Ischemia / complications
Prevalence
Chemical
Reg. No./Substance:
7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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