Document Detail

Should degenerated saphenous vein grafts routinely be sealed with drug-eluting stents?
MedLine Citation:
PMID:  16336427     Owner:  NLM     Status:  MEDLINE    
The percutaneous treatment of patients with obstructive atherosclerotic disease in degenerated coronary saphenous vein bypass grafts still remains one of the great challenges in interventional cardiology. In this review, we discuss the actual evidence-based knowledge for the percutaneous management of this lesion subset, focusing in particular on the devices that are actually considered the "gold standard" for this treatment: bare metal stents and distal protection devices. We also comment on the negative results of the randomized trials regarding the promising polytetrafluoroethylene-covered stent-grafts. We finally offer insights into the currently available evidence for the use of drug-eluting stents in saphenous vein grafts. These devices are potentially the principal promise for the long-term successful sealing of vein graft disease; however, clear and definitive data coming from controlled trials are requested.
Paul Vermeersch; Pierfrancesco Agostoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  18     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-73     Citation Subset:  IM    
Copyright Information:
(J Interven Cardiol 2005;18:467-473).
The Department of Cardiology, AZ Middelheim, Antwerp, Belgium.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Vessel Prosthesis Implantation*
Coronary Artery Bypass
Coronary Artery Disease / therapy*
Coronary Restenosis / prevention & control
Drug Delivery Systems
Evidence-Based Medicine
Immunosuppressive Agents / administration & dosage
Saphenous Vein / pathology,  transplantation*
Sirolimus / administration & dosage
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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