| Should complete blood count be part of the evaluation of febrile infants aged ≤2 months? | |
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MedLine Citation:
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PMID: 20367618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the utility and importance of total white blood cell count (WBC) and absolute neutrophil count (ANC) as markers of serious bacterial infection (SBI) in hospitalized febrile infants aged ≤2 months. PATIENTS AND METHODS: Data on WBC and ANC were collected prospectively for all infants aged ≤2 months who were hospitalized for fever at our centre. The patients were divided into two groups by the presence or absence of SBI. RESULTS: A total of 1257 infants met the inclusion criteria, of whom 134 (10.7%) had a SBI. The area under the ROC curve was 0.73 (95% CI: 0.67-0.78) for ANC, 0.70 (95% CI: 0.65-0.76) for %ANC and 0.69 (95% CI: 0.61-0.73) for WBC. The independent contribution of these three tests in reducing the number of missed cases of SBI was significant. CONCLUSION: Complete blood cell count should remain as part of the routine laboratory assessment in this age group as it is reducing the number of missing infants with SBI. Of the three parameters, ANC and %ANC serve as better diagnostic markers of SBI than total WBC. However, more accurate tests such as C-reactive protein and procalcitonin should also be part of the evaluation of febrile infants in these age group as they perform better than WBC or ANC for predicting SBI. |
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Authors:
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Efraim Bilavsky; Havatzelet Yarden-Bilavsky; Jacob Amir; Shai Ashkenazi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1380-4 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica. |
Affiliation:
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Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel. yoji@netvision.net.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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diagnosis* Biological Markers Female Fever of Unknown Origin / diagnosis* Humans Infant Infant, Newborn Leukocyte Count* Logistic Models Male Neutrophils / metabolism* ROC Curve Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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