| Should the bronchiectasis treatment given to cystic fibrosis patients be extrapolated to those with bronchiectasis from other causes? | |
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MedLine Citation:
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PMID: 20835588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To profile the characteristics of adult patients with bronchiectasis, drawing comparisons between cystic fibrosis (CF) patients and those with bronchiectasis from other causes in order to determine whether it is rational to extrapolate the bronchiectasis treatment given to CF patients to those with bronchiectasis from other causes. METHODS: A retrospective analysis of the medical charts of 87 patients diagnosed with bronchiectasis and under follow-up treatment at our outpatient clinic. Patients who had tuberculosis (current or previous) were excluded. We evaluated the clinical, functional, and treatment data of the patients. RESULTS: Of the 87 patients with bronchiectasis, 38 (43.7%) had been diagnosed with CF, through determination of sweat sodium and chloride concentrations or through genetic analysis, whereas the disease was due to another etiology in 49 (56.3%), of whom 34 (39.0%) had been diagnosed with idiopathic bronchiectasis. The mean age at diagnosis was lower in the patients with CF than in those without (14.2 vs. 24.2 years; p < 0.05). The prevalence of symptoms (cough, expectoration, hemoptysis, and wheezing) was similar between the groups. Colonization by Pseudomonas aeruginosa or Staphylococcus aureus was more common in the CF patients (82.4 vs. 29.7% and 64.7 vs. 5.4%, respectively). CONCLUSIONS: The causes and clinical manifestations of bronchiectasis are heterogeneous, and it is important to identify the differences. It is crucial that these differences be recognized so that new strategies for the management of patients with bronchiectasis can be developed. |
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Authors:
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Rodrigo Abensur Athanazio; Samia Zahi Rached; Ciro Rohde; Regina Carvalho Pinto; Frederico Leon Arrabal Fernandes; Rafael Stelmach |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia Volume: 36 ISSN: 1806-3756 ISO Abbreviation: J Bras Pneumol Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-05-13 Revised Date: 2011-10-11 |
Medline Journal Info:
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Nlm Unique ID: 101222274 Medline TA: J Bras Pneumol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 425-31 Citation Subset: IM |
Affiliation:
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Faculdade de Medicina, Universidade de São Paulo, Instituto do Coração, Hospital das Clínicas, São Paulo, Brasil. rathanazio@yahoo.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bronchiectasis / diagnosis*, etiology*, therapy Cystic Fibrosis / diagnosis* Female Humans Individualized Medicine* Male Middle Aged Retrospective Studies Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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