| Should blood flow during cardiopulmonary bypass be individualized more than to body surface area? | |
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MedLine Citation:
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PMID: 20736244 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Blood flow during cardiopulmonary bypass (CPB) is calculated on body surface area (BSA). Increasing comorbidity, age and weight of today's cardiac patients question this calculation as it may not reflect individual metabolic requirement. The hypothesis was that a measured cardiac index (CI) prior to normothermic CPB is a better estimate. A cross-over study, with random allocation to CPB blood flow for 20 minutes based on either a calculation (2.4 L/min/m(2)) or on CI, with a switch to the opposite flow for another 20 minutes, was performed. Twenty-two elective cardiac surgery patients with normal ventricular function were included. Effect parameters were cerebral oxygenation, mixed venous saturation and arterial lactate. CI varied from 1.9 to 3.1 L/min/m(2) (median 2.4 L/min/m(2)). No differences in effect parameters were seen. In conclusion, a CPB blood flow based on an individual estimate did not improve cerebral and systemic oxygenation compared to a blood flow based on BSA. |
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Authors:
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S A Thomassen; A Larsson; J J Andreasen; W Bundgaard; M Boegsted; B S Rasmussen |
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Publication Detail:
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Type: Journal Article Date: 2010-08-24 |
Journal Detail:
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Title: Perfusion Volume: 26 ISSN: 1477-111X ISO Abbreviation: Perfusion Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Denmark. siat@rn.dk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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