Document Detail

Should avoidance of foods be strict in prevention and treatment of food allergy?
MedLine Citation:
PMID:  20164762     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To discuss whether strict allergen avoidance is the most appropriate strategy for managing or preventing food allergy. RECENT FINDINGS: The standard of care for the management of food allergy has been strict allergen avoidance. This advice is based upon the suppositions that exposure could result in allergic reactions and avoidance may speed recovery. Recent studies challenge these assumptions. Studies now demonstrate that most children with milk and egg allergy tolerate extensively heated forms of these foods. Moreover, clinical trials of oral immunotherapy show that oral exposure can lead to desensitization. Additionally, recent epidemiologic studies fail to support the notion that delaying introduction of highly allergenic foods to infants and young children prevents the development of food allergy. In fact, the data suggest that delays may increase risks. SUMMARY: Recent data indicate that strict allergen avoidance is not always necessary for treatment, exposure may be therapeutic, and extended delay in introduction of food allergens to the diet of young children may increase allergy risks. However, in many circumstances strict avoidance is clearly necessary for treatment. Additional studies are needed to determine the risks and benefits of exposure to tolerated allergen, including identification of biomarkers to identify patients who may benefit.
Jennifer S Kim; Scott Sicherer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
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MeSH Terms
Allergens / immunology,  therapeutic use
Clinical Trials as Topic
Desensitization, Immunologic*
Dietary Proteins / immunology,  therapeutic use
Food Hypersensitivity / diet therapy*
Immune Tolerance
Reg. No./Substance:
0/Allergens; 0/Dietary Proteins

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