Document Detail

Should anti-D immunoglobulin be given antenatally?
MedLine Citation:
PMID:  6106109     Owner:  NLM     Status:  MEDLINE    
A survey of 246 Rh-negative expectant mothers who had Rh antibodies for the first time has shown that in about 50% sensitisation might have been prevented had anti-D immunoglobulin (Ig) been injected after delivery of the previous Rh-positive baby. Sensitisation of the other mothers could have been prevented only by giving anti-D Ig antenatally during pregnancy. Perinatal mortality and morbidity in Britain from Rh-haemolytic disease in first-affected babies is now so low that an attempt to eliminate Rh-haemolytic disease by giving anti-D Ig to all expectant Rh-negative mothers during the antenatal period is not cost effective. If all Rh-negative mothers who abort or give birth to an Rh-positive baby are injected with an adequate dose of anti-D Ig within 72 h of delivery, the small number of mothers in whom measures to prevent sensitisation have failed can be reduced by 50%.
G H Tovey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  466-8     Citation Subset:  AIM; IM    
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MeSH Terms
Costs and Cost Analysis
Erythroblastosis, Fetal / epidemiology,  prevention & control*
Great Britain
Immunoglobulins / administration & dosage*
Isoantibodies / immunology*
Prenatal Care
Rh-Hr Blood-Group System / immunology*
Reg. No./Substance:
0/Immunoglobulins; 0/Isoantibodies; 0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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