| Should all women with PCOS be treated for insulin resistance? | |
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MedLine Citation:
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PMID: 22192137 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PRO-A large majority of women with PCOS have insulin resistance, compensatory hyperinsulinemia with consequent reproductive and metabolic abnormalities. Metformin has been shown to be effective therapy and could be used more widely in obese adolescents with hyperandrogenemia, a forerunner of PCOS. CON-The severity of insulin resistance is highly variable in women with PCOS and may not be clinically relevant in milder phenotypes. Treatment should be directed at specific metabolic or reproductive problems and insulin sensitizing drugs are not always the optimum therapy. |
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Authors:
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John C Marshall; Andrea Dunaif |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 97 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Center for Research in Reproduction, Division of Endocrinology, University of Virginia, Charlottesville, Virginia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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