| Should albumin be used in all patients with spontaneous bacterial peritonitis? | |
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MedLine Citation:
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PMID: 21876859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with cirrhosis who develop spontaneous bacterial peritonitis (SBP) have been reported to experience a high incidence of renal impairment and mortality. Renal dysfunction is possibly related to altered systemic hemodynamics that leads to decreased effective arterial blood volume. Albumin, a plasma volume expander, has been investigated to determine whether it plays a role in patients with SBP. The current literature suggests that albumin can reduce renal impairment and mortality in high-risk SBP patients, defined as patients with a serum bilirubin level of greater than 68.4 μmol⁄L, a blood urea nitrogen level of greater than 10.7 mmol⁄L or a serum creatinine level greater than 88.4 μmol⁄L. The rationale for albumin and other volume expanders in SBP is discussed, accompanied by a review of the current literature. |
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Authors:
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Neeraj Narula; Keith Tsoi; John K Marshall |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Canadian journal of gastroenterology = Journal canadien de gastroenterologie Volume: 25 ISSN: 0835-7900 ISO Abbreviation: Can. J. Gastroenterol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-30 Completed Date: 2011-09-22 Revised Date: 2011-09-30 |
Medline Journal Info:
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Nlm Unique ID: 8807867 Medline TA: Can J Gastroenterol Country: Canada |
Other Details:
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Languages: eng Pagination: 373-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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administration & dosage,
pharmacology,
therapeutic use* Bilirubin / blood Humans Kidney Diseases / etiology Liver Cirrhosis / complications, drug therapy Peritonitis / complications, drug therapy* Plasma Substitutes / administration & dosage, pharmacology, therapeutic use* Renal Insufficiency / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Plasma Substitutes; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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