Document Detail

Should bilateral uterine artery notching be used in the risk assessment for preeclampsia, small-for-gestational-age, and gestational hypertension?
MedLine Citation:
PMID:  20587434     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the value of bilateral uterine artery notching in the second trimester in the risk assessment for preeclampsia, gestational hypertension, and small-for-gestational-age (SGA) without preeclampsia.
METHODS: This prospective cohort study included 4190 singleton pregnancies that underwent ultrasound examination between 23 and 25 weeks' gestation. The 95th percentiles of the mean pulsatility index (PI) and resistive index (RI) of both uterine arteries were calculated. Multivariable logistic regression analyses were performed to determine if bilateral uterine artery notching is an independent explanatory variable for the occurrence of preeclampsia, early-onset preeclampsia (<or=34 weeks), late-onset preeclampsia (>34 weeks), gestational hypertension, and delivery of an SGA neonate without preeclampsia, while controlling for confounding factors.
RESULTS: (1) The prevalence of preeclampsia, early-onset preeclampsia, late-onset preeclampsia, SGA, and gestational hypertension were 3.4%, 0.5%, 2.9%, 10%, and 7.9%, respectively; (2) 7.2% of the study population had bilateral uterine artery notching; and (3) bilateral uterine artery notching was an independent explanatory variable for the development of preeclampsia (odds ratio [OR], 2.1; 95% confidence interval [CI],1.28-3.36), early-onset preeclampsia (OR, 4.47; 95% CI, 1.50-13.35), and gestational hypertension (OR, 1.50; 95% CI, 1.02-2.26), but not for late-onset preeclampsia or SGA.
CONCLUSIONS: Bilateral uterine notching between 23 and 25 weeks' gestation is an independent risk factor for the development of early-onset preeclampsia and gestational hypertension. Thus, bilateral uterine artery notching should be considered in the assessment of risk for the development of these pregnancy complications.
Jimmy Espinoza; Juan Pedro Kusanovic; Ray Bahado-Singh; Maria Teresa Gervasi; Roberto Romero; Wesley Lee; Edi Vaisbuch; Shali Mazaki-Tovi; Pooja Mittal; Francesca Gotsch; Offer Erez; Ricardo Gomez; Lami Yeo; Sonia S Hassan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  29     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-12-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1103-15     Citation Subset:  IM    
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA.
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MeSH Terms
Fetal Growth Retardation / ultrasonography*
Gestational Age
Hypertension, Pregnancy-Induced / ultrasonography*
Pre-Eclampsia / ultrasonography*
Pregnancy Trimester, Second
Prospective Studies
Risk Assessment / methods
Ultrasonography, Prenatal*
Uterine Artery / ultrasonography*
Young Adult
Grant Support
Erratum In:
J Ultrasound Med. 2010 Oct;29(10):1494

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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