Document Detail


Shorter peripheral blood telomeres are a potential biomarker for patients with advanced colorectal adenomas.
MedLine Citation:
PMID:  22865299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Colorectal cancer (CRC) can be prevented by the early detection and removal of advanced adenomas (AAs) by colonoscopy. Our aim was to evaluate peripheral blood leukocyte (PBL) telomere length as a potential biomarker for the presence of AAs.
METHODS: PBL telomere length was measured in patients with AAs (n=35), in a control group of similarly aged patients who had a normal colonoscopy (n=145) and in a separate population group with no history of cancer, again similarly aged (n=495). Telomere measurements were performed using a quantitative PCR assay and reported as ratios of telomere and single copy gene measurements.
RESULTS: Telomere lengths tended to be lower in patients with AAs than in patients in the normal colonoscopy group (p<0.001) as well as those in the population group (p=0.011). A telomere/single copy gene ratio of 0.5 was found to have an estimated 94% sensitivity and a 56% specificity for AAs; a combination of sensitivity and specificity for which a value of >0.5 would reduce the odds of a patient having AAs by a factor of 0.11 (the negative likelihood ratio). Thirty three percent of individuals in the population group tested above this cutoff and could be considered at low risk for AAs.
CONCLUSIONS: PBL telomeres are shortened in patients with colorectal neoplasia, suggesting that PBL telomere length could be a promising non-invasive blood biomarker to pre-screen for risk of AAs prior to colonoscopy.
Authors:
Douglas L Riegert-Johnson; Lisa A Boardman; Julia E Crook; Colleen S Thomas; Ruth A Johnson; Maegan E Roberts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-27
Journal Detail:
Title:  The International journal of biological markers     Volume:  27     ISSN:  1724-6008     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    2012 Oct-Dec
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-09-05     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e375-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoma / blood,  genetics*,  pathology
Adult
Aged
Colonoscopy / methods
Colorectal Neoplasms / blood,  genetics*,  pathology
Female
Humans
Leukocytes / ultrastructure
Male
Middle Aged
Retrospective Studies
Telomere / metabolism,  ultrastructure*
Tumor Markers, Biological / blood,  genetics*
Grant Support
ID/Acronym/Agency:
CA 132718/CA/NCI NIH HHS; R01 CA132718/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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