Document Detail

Shorter abstinence decreases sperm deoxyribonucleic acid fragmentation in ejaculate.
MedLine Citation:
PMID:  21924714     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the relationship between duration of sexual abstinence and sperm selection on sperm DNA fragmentation (SDF).
DESIGN: Prospective study based on normozoospermic individuals.
SETTING: Fertility and IVF unit and university unit for research.
PATIENT(S): Two cohorts of normozoospermic individuals: 21 men (aged 25-35 years) attending a clinic and with clearly adverse female factors; and a group of 12 selected donors (aged 20-25 years).
INTERVENTION(S): SDF assessment using the sperm chromatin the dispersión test (Halosperm) in two cohorts of normozoospermic men.
MAIN OUTCOME MEASURE(S): SDF assessment after 24 hours of abstinence with recurrent ejaculation (one every 24 hours) using neat sperm samples; and SDF assessment before and after sperm selection with abstinence of 3 hours.
RESULT(S): Lower baseline levels of SDF were observed after shorter periods of abstinence between ejaculations (24 hours and 3 hours) than those recommended. This effect is much more marked after quick repetitive ejaculation (3 hours of abstinence) and sperm selection.
CONCLUSION(S): The present results challenge the role of abstinence in current male infertility treatments and suggest that SDF can be efficiently reduced by a biological practice consisting of short-term recurrent ejaculation coupled with effective sperm selection.
Jaime Gosálvez; Mercedes González-Martínez; Carmen López-Fernández; José L Fernández; Pascual Sánchez-Martín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-15
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2011-12-15     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Departamento de Biología, Unidad de Genética, Universidad Autónoma de Madrid, Madrid, Spain.
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MeSH Terms
DNA Fragmentation*
Infertility, Female / therapy*
Prospective Studies
Reproductive Techniques, Assisted*
Semen Analysis
Sexual Abstinence*
Spermatozoa / pathology*
Time Factors
Young Adult
Comment In:
J Urol. 2012 Jun;187(6):2170-1   [PMID:  22579200 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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