Document Detail

Shortening of vestibular nystagmus in response to velocity steps by microinjection of carbachol in the rabbit's cerebellar flocculus.
MedLine Citation:
PMID:  8454004     Owner:  NLM     Status:  MEDLINE    
It has been proposed that a common velocity-storage mechanism is responsible for the prolongation of vestibular nystagmus beyond the duration of the change in firing frequency of primary vestibular fibers in response to a step in velocity, and for the production of optokinetic afternystagmus (OKAN). In a previous study, bilateral injection of the aselective cholinergic agonist carbachol in the flocculus shortened the duration of buildup of optokinetic nystagmus (OKN) and the duration of OKAN, suggesting floccular involvement in velocity storage (Tan et al. 1992). In extension to that study of OKN, the present study assesses the effects of floccular carbachol on vestibular nystagmus in response to velocity steps. Our results show that injection of carbachol shortens the duration of vestibular nystagmus from about 13 to about 8 s; a finding which supports a common velocity-storage mechanism for optokinetic and vestibular signals. We propose that the indistinguishable effects of carbachol on OKAN and vestibular nystagmus are due to modification of the transmission of an oculomotor corollary signal, which has been identified electrophysiologically in the flocculus.
H S Tan; H Collewijn; J Van der Steen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental brain research     Volume:  92     ISSN:  0014-4819     ISO Abbreviation:  Exp Brain Res     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-21     Completed Date:  1993-04-21     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  IM; S    
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MeSH Terms
Carbachol / administration & dosage,  pharmacology*
Cerebellum / physiology*
Nystagmus, Optokinetic / physiology*
Photic Stimulation
Vestibule, Labyrinth / physiology*
Reg. No./Substance:

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