| Shortening of the ventricular fibrillatory intervals after administration of verapamil in a patient with Brugada syndrome and vasospastic angina. | |
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MedLine Citation:
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PMID: 16777521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 43-year-old man presented with electrocardiographic findings consistent with Brugada syndrome. Though the baseline coronary angiogram was normal, intracoronary infusion of ergonovine maleate caused complete occlusion of the left anterior descending and a 99% occlusion of the proximal right coronary artery, each relieved by intracoronary isosorbide dinitrate. Double extrastimuli delivered at the right ventricular outflow tract induced ventricular fibrillation terminated by a 200-J shock. Verapamil, 10 mg IV, increased ST-segment elevation and programmed stimulation repeated after the drug induced ventricular fibrillation with shorter F-F intervals and lower amplitude signals, which was not terminated by 200 J and required an additional 360-J shock. Ca2+ antagonism may have been adverse in this patient with Brugada syndrome because the drug has the potential to increase the voltage gradient through the right ventricle and to slow intraventricular conduction at very fast heart rates. |
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Authors:
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Masaomi Chinushi; Minoru Tagawa; Yuichi Nakamura; Yoshifusa Aizawa |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-02-28 |
Journal Detail:
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Title: Journal of electrocardiology Volume: 39 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-16 Completed Date: 2006-09-05 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 331-5 Citation Subset: IM |
Affiliation:
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School of Health Science, Niigata University School of Medicine, Japan. masaomi@clg.niigata-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angina Pectoris / complications, diagnosis, drug therapy* Anti-Arrhythmia Agents / administration & dosage Bundle-Branch Block / complications, drug therapy* Coronary Vasospasm / complications, diagnosis, drug therapy* Electrocardiography / drug effects* Humans Male Syndrome Treatment Outcome Ventricular Fibrillation / chemically induced*, diagnosis* Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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