Document Detail

Shortening Baroreflex Delay in Hypertrophic Cardiomyopathy Patients - An Unknown Effect of Beta-Blockers.
MedLine Citation:
PMID:  23126403     Owner:  NLM     Status:  Publisher    
AIM: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, impaired diastolic and systolic function. Abnormal sympathetic-parasympathetic balance is a potential stimulus for left ventricular hypertrophy in HCM patients. Beta-blockers are routinely used in HCM for their strong negative inotropic effect, however these drugs also influence the sympathetic-parasympathetic balance. This study aimed to determine the autonomic control of the cardiovascular system and the autonomic effects of beta-blockers in HCM patients treated or untreated with beta-blockers. METHODS: Among 51 HCM outpatient patients (18-70 years old; 29 men) there were 19 individuals with no medication and 32 subjects treated with beta-blocker. Additionally, 14 age- and gender-matched (23-70 years old; 9 men) healthy volunteers were enrolled in the control group. Continuous, noninvasive finger blood pressure was recorded in supine rest for 30 minutes. Autonomic regulation of the cardiovascular system was measured by heart rate variability (HRV) and spontaneous baroreflex function (cross-correlation sequence method). RESULTS: The mean pulse interval, time domain and spectral measures of HRV and baroreflex sensitivity were comparable between HCM patients treated or not with beta-blockers, and the control group. However, the delay of baroreflex was significantly longer in HCM patients untreated with beta-blockers (2.0 (1.6-2.3) s) in comparison with HCM patients on beta-blockers (1.4 (1.1-1.8) s; p=0.0072) or control subjects (1.2 (0.8-1.8) s; p=0.0025). This delay did not differ between HCM patients treated with beta-blockers and the control group. CONCLUSIONS: HCM not treated with beta-blockers is accompanied by prolonged baroreflex delay. The use of beta-blockers normalizes this delay.
A Katarzynska-Szymanska; R Ochotny; Z Oko-Sarnowska; H Wachowiak-Baszynska; T Krauze; J Piskorski; A Gwizdala; P Mitkowski; P Guzik
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  -     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
Department of Cardiology - First Department, Poznan University of Medical Sciences, Poznan, Poland.
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