| Shortened conditioned eyeblink response latency in male but not female Wistar-Kyoto hyperactive rats. | |
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MedLine Citation:
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PMID: 19485572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reductions in the volume of the cerebellum and impairments in cerebellar-dependent eyeblink conditioning have been observed in attention-deficit/hyperactivity disorder (ADHD). Recently, it was reported that subjects with ADHD as well as male spontaneously hypertensive rats (SHR), a strain that is frequently employed as an animal model in the study of ADHD, exhibit a parallel pattern of timing deficits in eyeblink conditioning. One criticism that has been posed regarding the validity of the SHR strain as an animal model for the study of ADHD is that SHRs are not only hyperactive but also hypertensive. It is conceivable that many of the behavioral characteristics seen in SHRs that seem to parallel the behavioral symptoms of ADHD are not solely due to hyperactivity but instead are the net outcome of the interaction between hyperactivity and hypertension. We used Wistar-Kyoto Hyperactive (WKHA) and Wistar-Kyoto Hypertensive (WKHT) rats (males and females), strains generated from recombinant inbreeding of SHRs and their progenitor strain, Wistar-Kyoto (WKY) rats, to compare eyeblink conditioning in strains that are exclusively hyperactive or hypertensive. We used a long-delay eyeblink conditioning task in which a tone conditioned stimulus was paired with a periorbital stimulation unconditioned stimulus (750-ms delay paradigm). Our results showed that WKHA and WKHT rats exhibited similar rates of conditioned response (CR) acquisition. However, WKHA males displayed shortened CR latencies (early onset and peak latency) in comparison to WKHT males. In contrast, female WKHAs and WKHTs did not differ. In subsequent extinction training, WKHA rats extinguished at similar rates in comparison to WKHT rats. The current results support the hypothesis of a relationship between cerebellar abnormalities and ADHD in an animal model of ADHD-like symptoms that does not also exhibit hypertension, and suggest that cerebellar-related timing deficits are specific to males. |
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Authors:
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Alexandra Thanellou; Kira M Schachinger; John T Green |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Behavioral neuroscience Volume: 123 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-02 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 650-64 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 APA, all rights reserved. |
Affiliation:
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Department of Psychology, University of Vermont, Burlington, VT 05405-0134, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Analysis of Variance Animals Attention Deficit Disorder with Hyperactivity / physiopathology, psychology Blinking / physiology Conditioning, Eyelid / physiology* Disease Models, Animal Electromyography Extinction, Psychological / physiology Female Hypertension / physiopathology*, psychology* Male Psychomotor Agitation / physiopathology*, psychology* Rats Rats, Inbred WKY Sex Characteristics* Species Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR16435/RR/NCRR NIH HHS; P20 RR16462/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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