| Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes. | |
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MedLine Citation:
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PMID: 21343541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the fundamental defect in both type 1 and type 2 diabetes is β-cell failure, there is increasing interest in the capacity, if any, for β-cell regeneration. Insights into typical β-cell age and lifespan during normal development and how these are influenced in diabetes is desirable to realistically establish the prospects for β-cell regeneration as means to reverse the deficit in β-cell mass in diabetes. We assessed the mean β-cell age and lifespan by the classical McKendrick-von Foester equation that describes the age-based heterogeneity of β-cells in terms of the time-varying β-cell formation and loss estimated by a β-cell turnover model. This modeling approach was applied to evaluate β-cell lifespan in a rodent model of type 2 diabetes in comparison with nondiabetic controls. When rats were 10 mo old, mean β-cell lifespan was 1 mo vs. 6 mo in rats with type 2 diabetes vs. controls. A shortened β-cell lifespan in a rat model of type 2 diabetes results in a decrease in mean β-cell age and thus contributes to decreased β-cell mass. |
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Authors:
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Erica Manesso; Gianna M Toffolo; Alexandra E Butler; Peter C Butler; Claudio Cobelli |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-22 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 300 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-27 Completed Date: 2011-06-28 Revised Date: 2013-02-14 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E933-8 Citation Subset: IM |
Affiliation:
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Dept. of Information Engineering, Univ. of Padova, Via Gradenigo 6 B, 35129 Padova, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Algorithms Animals Animals, Genetically Modified Apoptosis / physiology Cell Count Cell Death / physiology Diabetes Mellitus, Type 2 / genetics, pathology* Humans In Situ Nick-End Labeling Insulin-Secreting Cells / pathology* Longevity / physiology* Models, Statistical Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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DK-077967/DK/NIDDK NIH HHS; R01 DK059579/DK/NIDDK NIH HHS; R01 DK059579-12/DK/NIDDK NIH HHS; R01 DK077967-05/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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