Document Detail


Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes.
MedLine Citation:
PMID:  21343541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since the fundamental defect in both type 1 and type 2 diabetes is β-cell failure, there is increasing interest in the capacity, if any, for β-cell regeneration. Insights into typical β-cell age and lifespan during normal development and how these are influenced in diabetes is desirable to realistically establish the prospects for β-cell regeneration as means to reverse the deficit in β-cell mass in diabetes. We assessed the mean β-cell age and lifespan by the classical McKendrick-von Foester equation that describes the age-based heterogeneity of β-cells in terms of the time-varying β-cell formation and loss estimated by a β-cell turnover model. This modeling approach was applied to evaluate β-cell lifespan in a rodent model of type 2 diabetes in comparison with nondiabetic controls. When rats were 10 mo old, mean β-cell lifespan was 1 mo vs. 6 mo in rats with type 2 diabetes vs. controls. A shortened β-cell lifespan in a rat model of type 2 diabetes results in a decrease in mean β-cell age and thus contributes to decreased β-cell mass.
Authors:
Erica Manesso; Gianna M Toffolo; Alexandra E Butler; Peter C Butler; Claudio Cobelli
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-22
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  300     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-27     Completed Date:  2011-06-28     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E933-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Algorithms
Animals
Animals, Genetically Modified
Apoptosis / physiology
Cell Count
Cell Death / physiology
Diabetes Mellitus, Type 2 / genetics,  pathology*
Humans
In Situ Nick-End Labeling
Insulin-Secreting Cells / pathology*
Longevity / physiology*
Models, Statistical
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DK-077967/DK/NIDDK NIH HHS; R01 DK059579/DK/NIDDK NIH HHS; R01 DK077967/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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