| Shortcut access to peptidosteroid conjugates: building blocks for solid-phase bile Acid scaffold decoration by convergent ligation. | |
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MedLine Citation:
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PMID: 22157580 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We present three versatile solid-supported scaffold building blocks based on the (deoxy)cholic acid framework and decorated with handles for further derivatization by modern ligation techniques such as click chemistry, Staudinger ligation or native chemical ligation. Straightforward procedures are presented for the synthesis and analysis of the steroid constructs. These building blocks offer a new, facile and shorter access route to bile acid-peptide conjugates on solid-phase with emphasis on heterodipodal conjugates with defined spatial arrangements. As such, we provide versatile new synthons to the toolbox for bile acid decoration. |
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Authors:
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Dieter Verzele; Sara Figaroli; Annemieke Madder |
Publication Detail:
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Type: Journal Article Date: 2011-12-07 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 16 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 10168-86 Citation Subset: IM |
Affiliation:
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Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Faculty of Sciences, Ghent University, B-9000 Ghent, Belgium. annemieke.madder@ugent.be. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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