| Short versus long course of prophylactic antibiotics. | |
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MedLine Citation:
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PMID: 7048929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of prophylactic antibiotics to reduce post-cesarean section febrile morbidity has been advocated since 1968. Although this approach has theoretical and actual disadvantages, all but one study found a reduction in febrile morbidity when prophylactic antibiotics were used. An unresolved question was the duration of antibiotic therapy. A double-blind randomized study compared a long course of ampicillin (3 days) to a short course of ampicillin (three doses) to placebo. The long course of prophylactic antibiotics reduced febrile morbidity significantly better (p less than 0.025) than the short course, and hospital stay was also significantly reduced when compared to placebo (significance, p less than 0.01). A longer course (3 days) of antibiotics was superior to a short course (three doses) in situations in which prophylactic antibiotics were used. |
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Authors:
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J P Elliott; R K Freeman; W Dorchester |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 143 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1982 Aug |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 740-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Ampicillin / administration & dosage Anti-Bacterial Agents / administration & dosage* Cesarean Section* / adverse effects Clinical Trials as Topic Double-Blind Method Female Fever / prevention & control Hospitalization Humans Injections, Intravenous Pregnancy Premedication* Random Allocation Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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