Document Detail


Short-term voluntary exercise in the rat causes bone modeling without initiating a physiological stress response.
MedLine Citation:
PMID:  20668232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent research has revealed a neuroendocrine connection between the skeleton and metabolism. Exercise alters both bone modeling and energy balance and may be useful in further developing our understanding of this complex interplay. However, research in this field requires an animal model of exercise that does not cause a physiological stress response in the exercised subjects. In this study, we develop a model of short-term voluntary exercise in the female rat that causes bone modeling without causing stress. Rats were randomly assigned to one of three age-matched groups: control, tower climbing, and squat exercise (rising to an erect bipedal stance). Exercise for 21 days resulted in bone modeling as assessed by peripheral quantitative computed tomography. Fecal corticosterone output was used to assess physiological stress at three time points during the study (preexercise, early exercise, and late in the exercise period). There were no differences in fecal corticosterone levels between groups or time points. This model of voluntary exercise in the rat will be useful for future studies of the influence of exercise on the relationship between skeletal and metabolic health and may be appropriate for investigation of the developmental origins of those effects.
Authors:
Brielle V Rosa; Elwyn C Firth; Hugh T Blair; Mark H Vickers; Patrick C H Morel; John F Cockrem
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-28
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  299     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-01     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1037-43     Citation Subset:  IM    
Affiliation:
National Research Centre for Growth and Development, Institute of Veterinary, Animal and Biomedical Sciences, Massey Univ., Palmerston North, New Zealand. B.V.Rosa@massey.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Animals
Behavior, Animal / physiology
Body Weight / physiology
Bone Density / physiology
Bone Remodeling / physiology*
Corticosterone / blood
Diaphyses / anatomy & histology
Eating / physiology
Feces / chemistry
Female
Physical Conditioning, Animal / physiology*
Rats
Rats, Wistar
Stress, Physiological / physiology*
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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