Document Detail

Short term variability of single breath carbon monoxide transfer factor.
MedLine Citation:
PMID:  11312403     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When monitoring patients with chronic lung disease it is important to distinguish genuine changes in gas transfer over time from natural variability. This study aims to define the coefficient of repeatability for routine measurements of single breath transfer factor (TCO) and transfer coefficient (KCO). METHODS: Sixty eight subjects (32 with emphysema, 36 healthy volunteers) had TCO measured twice at a mean (SD) interval of 7.5 (1.3) days. On each occasion a standard protocol (conforming to BTS guidelines) was followed, comprising duplicate measurements satisfying standard technical criteria. The mean of these duplicates was recorded. For the pooled data changes in TCO and KCO between study days were expressed as coefficient of repeatability. RESULTS: The coefficient of repeatability was +/-1.60 mmol/min/kPa for TCO and +/-0.24 mmol/min/kPa/l for KCO. Correcting TCO and KCO for prevailing barometric pressure or carboxyhaemoglobin level made no significant difference to the results. CONCLUSIONS: The quoted limits for variability in gas transfer over time are valid for a wide range of clinically relevant values. Changes in TCO and KCO greater than these limits are unlikely to arise from natural variation.
A G Robson; J A Innes
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  56     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-04-20     Completed Date:  2001-05-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  IM    
Respiratory Function Laboratory, Western General Hospital, Edinburgh EH4 2XU, UK.
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MeSH Terms
Carbon Monoxide / metabolism*
Carboxyhemoglobin / analysis
Partial Pressure
Pulmonary Emphysema / metabolism*,  physiopathology
Pulmonary Gas Exchange / physiology*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

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