Document Detail

Short-term use of Goserelin depot in the treatment of dysfunctional uterine bleeding.
MedLine Citation:
PMID:  7554259     Owner:  NLM     Status:  MEDLINE    
PATIENTS: 60 premenopausal women (aged 36-50) with dysfunctional uterine bleeding, presenting simple endometrial hyperplasia.
RESULTS: after the treatment, spontaneous menstrual bleeding recurred in 57/60 patients, while 3/60 (5%) patients remained amenorrheal during the whole period of follow-up, showing a postmenopausal hormonal pattern. In the first post-therapy menstrual cycle all the 57 patients had a bleeding score < 100; patients relapsing during the second, third and fourth cycle were respectively 2/54 (3.7%), 5/48 (10.7%) and 17/38 (44.7%). The fourth post-therapy cycle was delayed 6-9 months after the last injection of Goserelin. Both the mean blood loss and the mean duration of bleeding were significantly reduced in all post-therapy cycles. Eleven patients were anaemic before therapy (Hb < 12 g%); Goserelin treatment resulted in a normalization of the hematological parameters. At the end of treatment a small area of hyperplasia persisted in only 4/60 patients (6.7%). Localised or diffused hyperplasia were found respectively in 5/54 (9.3%) and in 1/54 patients (1.9%) at three months, and in 5/48 (10.4%) and 4/48 (8.3%) at a six-month follow-up. Side effects were infrequent.
CONCLUSIONS: the long symptom-free period and the low incidence of side effects indicates Goserelin depot as a valuable medical treatment for dysfunctional uterine bleeding.
N Colacurci; G De Placido; A Mollo; A Perino; E Cittadini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  22     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2011-01-11    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  212-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, 2nd Medical School, Naples, Italy.
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MeSH Terms
Delayed-Action Preparations / therapeutic use
Dose-Response Relationship, Drug
Endometrial Hyperplasia / complications
Goserelin / therapeutic use*
Menorrhagia / drug therapy*,  etiology
Metrorrhagia / drug therapy*,  etiology
Middle Aged
Reg. No./Substance:
0/Delayed-Action Preparations; 65807-02-5/Goserelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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