| Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans. | |
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MedLine Citation:
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PMID: 20852882 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Short-term leg immobilization is an acute model of inactivity, which induces vascular deconditioning. The present study was conducted to determine if short-term leg immobilization induced alterations in central and peripheral conduit artery structure (diameter and compliance), function (resting blood flow and mean wall shear rate), and peripheral flow-mediated dilation. Healthy participants (n = 7 women and n = 8 men) were studied before and after 12 days of unilateral leg immobilization. Carotid artery structure and function were unaltered with immobilization indicating that the unilateral immobilization did not have a detectable effect on this representative central artery. In contrast, peripheral measures of arterial structure at the common femoral and popliteal arteries showed significant reductions in both the immobilized and non-immobilized limbs but to a greater extent in the immobilized limbs. Specifically, femoral and popliteal artery compliance and femoral artery diameter were reduced in both the immobilized and the non-immobilized limb (p < 0.05) while popliteal artery diameter was reduced only in the immobilized leg. Popliteal artery flow-mediated dilation, an indicator of peripheral artery function, was increased in the immobilized limb, which parallels reports in paralyzed limbs of spinal-cord-injured individuals. The time course of vascular alterations with inactivity likely follows a sequence of adaptations in arterial structure and function reflecting differing initial flow patterns, and arterial wall composition, and diverse hemodynamic stimuli within different blood vessels. |
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Authors:
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Mark Rakobowchuk; Jennifer Crozier; Elisa I Glover; Nobuo Yasuda; Stuart M Phillips; Mark A Tarnopolsky; Maureen J MacDonald |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-18 |
Journal Detail:
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Title: European journal of applied physiology Volume: 111 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 203-10 Citation Subset: IM |
Affiliation:
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Department of Kinesiology, McMaster University, Hamilton, ON, Canada. m.e.rakobowchuk@leeds.ac.uk |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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